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In vitro ADME and PK

ADME and Pharmacokinetic Services

Our in vitro ADME and DMPK services include in vitro metabolism, in vitro permeability and transporters, solubility and physicochemical properties, in vitro protein binding and PK and bioanalysis

  • Highly reproducible, accurate data - validated and used by over 1700 clients from the pharmaceutical, biotechnology, agrochemical, tobacco, cosmetics, health care companies and academic and government organisations.
  • Delivery of data for core in vitro ADME screening and physicochemical assays is within 10 working days to fit in with the make-test timelines in drug discovery. A number of different reporting options are available.
  • Highly cost effective due to our emphasis on high throughput engineering for key in vitro screening assays.
  • Attention to good quality customer care, with highly trained Principal Scientists on hand to explain results and suggest the most appropriate experimental strategy.
  • Flexibility - studies can be tailored to our customers’ specific requirements.
  • Regulations - our ADME services maintain and comply with regulatory guidelines providing constant confidence in the data.

Our facility has passed evaluations by a range of different organisations and companies from a variety of differing industries, including government agencies: All now routinely use our services to provide support to their programs.

ADME and PK Services

In Vitro Metabolism
Cytochrome P450 and UGT Reaction Phenotyping
Cytochrome P450 Induction
Cytochrome P450 Inhibition
Cytochrome P450 Ki
Hepatocyte Stability
Low Clearance Hepatocyte Stability
Hepatic Uptake
Metabolite Profiling and Identification
Microsomal Binding
Microsomal Stability
Plasma Stability
PXR and AhR Nuclear Receptor Activation
S9 Stability
Time Dependent Inhibition (IC50 Shift)
Time Dependent Inhibition (kinact/KI )
Time Dependent Inhibition (single point)
UGT Inhibition
In Vitro Permeability and Transporters
Caco-2 Permeability
PAMPA
MDR1-MDCK Permeability (P-gp substrate identification)
Wild type MDCK Permeability
P-gp Inhibition
BCRP Substrate Identification
BCRP Inhibition
SLC Transporter Substrate Identification (OATP1B1, OATP1B3, OAT1, OAT3, OCT1, OCT2, MATE1, MATE2-K, OATP1A2, OATP2B1, OAT2, OAT4, OCTN2, PEPT1, PEPT2, NTCP)
SLC Transporter Inhibition (OATP1B1, OATP1B3, OAT1, OAT3, OCT1, OCT2, MATE1, MATE2-K, OATP1A2, OATP2B1, OAT2, OAT4, OCTN2, PEPT1, PEPT2, NTCP)
BSEP Inhibition
Single and Double Transporter Knockout Cell-Based Service
Other transporter assays available on request
Polymorphic and Non-CYP Mediated Metabolism
Monoamine Oxidase Inhibition
Monoamine Oxidase Reaction Phenotyping
Carboxylesterase Inhibition
Carboxylesterase Reaction Phenotyping
Aldehyde Oxidase Reaction Phenotyping
Protein Binding
Brain Tissue Binding
Plasma Protein Binding
Whole Blood Binding
Blood to Plasma Ratio
Bioanalysis
Advanced Bioanalytical Method Development, Method Transfer and Method Qualification
Pharmacokinetics (PK) Services
Prodrug Services

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ADME-Tox Guides Pricing & Discounts

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Telephone:
North America (East Coast): 888-297-7683
Europe: +44 1625 505100

 

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Please give details of the assays you are interested in. Where appropriate please specify one or more species (human, rat, mouse etc.), isoforms (CYP1A1,CYP1B1, etc) or other relevant details.

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