In vitro ADME and PK
ADME and Pharmacokinetic Services
Our in vitro ADME and DMPK experimental service includes in vitro metabolism, in vitro permeability and transporters, solubility and physicochemical properties, in vitro protein binding and PK and bioanalysis
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Our facility has passed evaluations by a range of different companies and organisations who now routinely use our services to provide support to their programs.
ADME and PK Services
| In vitro permeability |
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| in vitro transporter assays |
| Caco-2 permeability |
| MDCK (wild type) permeability |
| MDR1-MDCK permeability |
| P - glycoprotein inhibition |
| PAMPA |
| Bioanalysis |
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| bioanalytical method development and validation |
| Physicochemical properties |
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| chemical stability |
| CHI |
| log D |
| pKa and log P determination |
| thermodynamic solubility |
| turbidimetric solubility |
| Protein binding |
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| blood to plasma ratio |
| brain tissue binding |
| plasma protein binding |
| whole blood binding |
Find out more about our:
Can't see the assay you need?
Please contact our Product Development Team with your requirements.
Genomic ADME - gADME™
Cyprotex's proprietary gADME™ system can alert you to genetic variations in drug metabolism, allowing for personalised doses, drug rescue and repositioning.
Learn more about gADME
In vitro Micronucleus Test
Cyprotex now offers the in vitro micronucleus test for genotoxicity assessment using an automated, high content screening method for improved detection and reliability.
Learn more about our in vitro MNT service
Drug Transporters
Cyprotex provides a full range of drug-transporter studies as recommended by the ITC white paper and EMA guidelines.
Learn more about transporters
By Dr. Katya Tsaioun, Chief Scientific Officer, Cyprotex
Wiley & Sons, March 2011
