Because genomic biomarkers are frequently more sensitive than the traditional, functional and morphological markers, they represent a useful supplement to more reliably detect hepatotoxicity in short term studies, where the full phenotypic manifestation of toxicity may not have fully developed.
3 Blomme EAG, Yang Y, Waring JF (2009) Toxicology Letters 186; 22–31
1 McMillian M et al. (2004) Biochem Pharmacol 67; 2141–2165
2 McMillian M et al. (2004) Biochem Pharmacol 68; 2249–2261
3 Blomme EAG et al. (2009) Toxicology Letters 186; 22–31