Cloe® Screen
In vitro ADME screening service
Our in vitro ADME screening service offers a portfolio of assays for investigating: in vitro metabolism, in vitro permeability, solubility & physicochemical properties and protein binding. Cloe® Screen delivers consistent, accurate compound data with cost-efficiency that comes from a highly automated approach.
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Cloe® Screen has passed evaluations by both large pharmaceutical and smaller biotechnology partners who now routinely use Cloe® Screen to support their drug discovery.
Cloe® Screen Services
| In vitro permeability |
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| PAMPA |
| Caco-2 permeability |
| MDCK (wild type) permeability |
| MDR1-MDCK permeability |
| in vitro transporter assays |
| Physicochemical properties |
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| turbidimetric solubility |
| thermodynamic solubility |
| CHI |
| log D |
| chemical stability |
| Protein binding |
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| plasma protein binding |
| whole blood binding |
Additional services are available - see Cloe® Select
Can't see the assay you need?
Please contact our Product Development Team with your requirements.
Genomic ADME - gADME™
Cyprotex's proprietary gADME™ system can alert you to genetic variations in drug metabolism, allowing for personalised doses, drug rescue and repositioning.
Learn more about gADME
In vitro Micronucleus Test
Cyprotex now offers the in vitro micronucleus test for genotoxicity assessment using an automated, high content screening method for improved detection and reliability.
Learn more about our in vitro MNT service
Drug Transporters
Cyprotex provides a full range of drug-transporter studies as recommended by the ITC white paper and EMA guidelines.
Learn more about transporters
By Dr. Katya Tsaioun, Chief Scientific Officer, Cyprotex
Wiley & Sons, March 2011
