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Cloe^® Select

Bespoke ADME and DMPK experimental service

Our Cloe® Select ADME and DMPK experimental service is designed to meet the requirements of later stage studies. Services include: in vitro metabolism, in vitro permeability, in vitro protein binding and physicochemical properties and PK and bioanalysis. Cloe® Select offers the following benefits:

Flexibility - a portfolio of bespoke studies which can be customised to individual requirements.

Regulations - as with our Cloe® Screen ADME screens, our Cloe® Select service maintains and complies with regulatory guidelines providing constant confidence in the data received.

Results - a number of different reporting options are available from summary data to full written reports.

Consultancy - studies overseen by a single highly experienced and dedicated Principal Scientist who provides a high level of support and guidance prior to, during, and after the study.

Cloe^® Select Services

In vitro metabolism
metabolite profiling and identification
cytochrome P450 induction
cytochrome P450 Ki
time dependent inhibition (k_inact/K_I )
UGT1A1 inhibition

In vitro permeability
P - glycoprotein inhibition

Bioanalysis
bioanalytical method development and validation

Physicochemical properties
pKa and log P determination

Protein binding
brain tissue binding
blood to plasma ratio

Additional services are available under Cloe^® Screen

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Genomic ADME - gADME™

Cyprotex's proprietary gADME™ system can alert you to genetic variations in drug metabolism, allowing for personalised doses, drug rescue and repositioning.
Learn more about gADME

In vitro Micronucleus Test

Cyprotex now offers the in vitro micronucleus test for genotoxicity assessment using an automated, high content screening method for improved detection and reliability.
Learn more about our in vitro MNT service

Drug Transporters

Cyprotex provides a full range of drug-transporter studies as recommended by the ITC white paper and EMA guidelines.
Learn more about transporters

ADMET for Medicinal Chemists: A Practical Guide
By Dr. Katya Tsaioun, Chief Scientific Officer, Cyprotex
Wiley & Sons, March 2011

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