In vitro permeability

Cyprotex as a specialist of ADME and PK profice a range of in vitro permeability assays and these include PAMPA, Caco-2, MRD1-MDCK assays.

For confirmation of the role of human P-gp in MDR1-MDCK studies screening through wild type MDCK is recommended.

P-gp Inhibition

For understanding of the potential of a drug candidate to influence the absorption of other xenobiotics a MDCK P-gp inhibition assay is provided.