your speakers for our 2 events

Biography

Michael Griffin has been a project manager at Cyprotex for 3 years. Michael is responsible for managing client studies within Cyprotex and the day to day interactions with clients. Prior to this Michael completed his PhD within Brian Houston’s group at the University of Manchester. The title of his PhD was the “Use of in vitro metabolism models for in vivo drug metabolic clearance prediction”. This work was particularly focused on the utility of microsomes and hepatocytes for the prediction of in vivo clearance and the investigation of improvements to in vitro to in vivo model prediction. Previous to this Michael worked was a research scientist within the DMPK department at Vernalis for 3 years where he developed a wide range of metabolism and permeability screens.

ADME training course objective

This course is designed for personnel in the pharmaceutical and biotechnology industries and contract research organisations who want to understand the rationale, methodology and importance of in vitro ADME and DMPK studies during the drug discovery and development processes. This course is focused at individuals within industry wanting to expand their knowledge of in vitro ADME and DMPK for example, medicinal chemists wishing to understand the importance of early ADME testing or project managers wanting to understand the DMPK profile of lead compounds.

The various types of in vitro ADME and DMPK studies will be discussed detailing the benefits of performing these assays early in drug discovery, an overview of the methodologies currently available and how these data can be used to make informed decisions based upon a compounds overall ADME/DMPK profile.