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Cyprotex Launch New Endocrine Disruption Service

Cyprotex PLC
("Cyprotex" or "the Company")
Cyprotex Launch New Endocrine Disruption Service

  Cyprotex PLC (AIM:CRX), a specialist Contract Research Organisation (CRO), announced today the launch of a new endocrine disruption service to evaluate androgen receptor modulation.

 Endocrine disruptors are chemicals which can interfere with the hormonal systems within the body. These chemicals can potentially lead to adverse effects on the developmental, reproductive, neurological and immune systems, and there are reports that the increased incidence in cancers, diabetes, obesity and reduced fertility over the last 50 years may be attributed to endocrine disruption. Specifically, chemicals which disrupt the androgen receptor can lead to reduced sperm count, infertility, prostate cancer and interference with normal male reproductive development.

 The mechanism by which the androgen receptor is activated is by binding of a chemical or hormone in the cytoplasm of the cell resulting in translocation (movement) of the receptor into the nucleus of the cell. The new androgen receptor modulation assay offered by Cyprotex uses sophisticated high content imaging techniques to monitor this translocation process through fluorescently tagged proteins. The method has the advantage that both activation (agonist effects) and inhibition (antagonist effects) of the androgen receptor can be distinguished between.

Dr Anthony Baxter, Cyprotex’s Chief Executive Officer, comments: “Within the agrochemical and industrial chemical industries, endocrine disruptors are of considerable concern due to their potential adverse effects on the environment and the general population. Bodies such as the Environmental Protection Agency (EPA) in the USA and REACH within Europe play an important role in regulating chemicals and ensuring risk from endocrine disruptors is minimised through effective testing strategies. Cyprotex are recognised experts in this field and already have a comprehensive range of screening and regulatory test methods available. Introducing the new androgen receptor modulation assay complements these existing services, and provides an in-depth analysis of cellular processes involved in endocrine disruption.”

For Further Information

Cyprotex PLC 
Tel: +44 (0) 1625 505 100
Dr Anthony Baxter, Chief Executive Office
John Dootson, Chief Financial Officer
Mark Warburton, Chief Operating Officer and Legal Counsel
ir@cyprotex.com
www.cyprotex.com

N+1 Singer (Nomad and broker to Cyprotex)
Tel: +44 (0)20 7496 3000
Shaun Dobson
shaun.dobson@n1singer.com
Jen Boorer
jennifer.boorer@n1singer.com
www.nplus1singer.com

Cyprotex PLC

Cyprotex is listed on the AIM market of the London Stock Exchange (CRX). It has sites at Macclesfield and Alderley Park, both of which are near Manchester in the UK, and at Watertown, MA and Kalamazoo, MI in the US. The Company was established in 1999 and works with more than 1400 partners within the pharmaceutical and biotech industry, cosmetics and personal care industry and the chemical industry. Cyprotex acquired Apredica and the assets of Cellumen Inc. in August 2010 and the combined business provides support for a wide range of experimental and computational ADME-Tox and PK services. The acquisition of the assets and business of CeeTox in January 2014 has enabled Cyprotex to expand its range of services to target the personal care, cosmetics and chemical industries. In 2015, Cyprotex launched its new bioscience division to expand its capabilities into phenotypic and target based screening. The Company’s core capabilities include high quality in vitro ADME services, mechanistic toxicology and high content toxicology screening services, including our proprietary CellCiphr® toxicity prediction technology, bioscience services, predictive modelling solutions including Cloe® PK, chemPK™, chemTarget and chemTox, and a range of skin, ocular and endocrine disruption services. For more information, please visit www.cyprotex.com.

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