NOTIFICATION OF INTERESTS OF DIRECTORS AND CONNECTED PERSONNEL 

1.          Name of company 

            CYPROTEX PLC 

2.          Name of Director 

            JOHN ANDREW NICHOLSON 

3.          Please state whether notification indicate that it is in respect of holding of the shareholder named in 2 above or in respect of a non-beneficial interest or in the case of an individual holder if it is a holding of that personÕs spouse or children under the age of 18 or in respect of a non-beneficial interest. 

            DIRECTOR 

4.          Name of the registered holder(s) and, if more than one holder, the number of shares held by each of them (if notified) 

            JOHN A NICHOLSON 17,500             -            SHARES HELD IN OWN NAME 

            TOTAL             -            17,500 

5.          Please state whether notification relates to a person(s) connected with the Director named in 2 above and identify the connected person(s). 

            DIRECTOR 

6.          Please state the nature of the transaction.  For PEP transactions please indicate whether general/single co PEP and if discretionary/non discretionary. 

            GRANT OF NEW SHARE OPTIONS 

7.          Number of shares/amount of stock acquired 

            NIL 

8.          Percentage of issued class 

            0.00% 

9.          Number of shares/amount of stock disposed 

            NIL 

10.         Percentage of issued class

            NIL 

11.        Class of security 

12.        Price per share 

13.        Date of transaction 

14.        Date company informed 

15.        Total holding following this notification 

            JOHN NICHOLSON             -            17,500 SHARES HELD IN OWN NAME 

            TOTAL             -            17,500  (NO CHANGE) 

16.        Total percentage holding of issued class following this notification 

            0.019% 

If a director has been granted options by the company please complete the following boxes 

17.        Date of grant 

            3 JULY 2002 

18.        Period during which or date on which exercisable 

            OVER 22 MONTHS FOLLOWING 6 FEBRUARY 2004 

19.        Total amount paid (if any) for grant of the option 

            NIL 

20.        Description of shares or debentures involved : class, number 

            ORDINARY SHARES AT  0.1p 

21.        Exercise price (if fixed at time of grant) or indication that price is to be fixed at time of exercise 

            9.25p 

22.        Total number of shares or debentures over which options held following this notification 

            2,048,276 

23.        Any additional information 

24.        Name of contact and telephone number for queries 

            GILL RITCHIE - (01625) 505121 

            COMPANY SECRETARY 

25.        Name and signature of authorised company official responsible for making this notification 

            DR DAVID LEAHY 

            JOINT CEO AND CHIEF SCIENTIFIC OFFICER 

            Date of notification: 7 July 2003