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22 May 2003

Closure of Spread Bet

Cyprotex PLC ("the Company") has received today a letter from City Index Limited confirming that all spread bets placed by Paul Davidson with City Index Limited in relation to Cyprotex plc have been unconditionally closed.

For further information:

Dr David Leahy, Joint Chief Executive Officer, Chief Scientific Officer
John Nicholson, Joint Chief Executive Officer, Chief Operating Officer
Cyprotex PLC
Tel: +44 (0) 1625 505 100
j.nicholson@cyprotex.com
d.leahy@cyprotex.com
www.cyprotex.com

Phil Adams
Altium Capital
Tel: +44(0) 161 831 1203

Media enquiries:

Heather Salmond / Julian Bosdet (for Cyprotex)
Bankside Consultants Limited
Tel: +44 (0) 20 7444 4140
www.bankside.com

Ken Cronin / Neil Bennett (for City Index)
Gavin Anderson
Tel: +44 (0)20 7554 1400

News Contact:

Robert Morrisson Atwater, Chairman & CEO
+44 1625 505 152
ir@cyprotex.com
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