21 December 2004

NOTIFICATION OF INTERESTS OF DIRECTORS AND CONNECTED PERSONS

1. Name of Company

CYPROTEX PLC

2. Name of director

ROBERT MORRISSON ATWATER

3. Please state whether notification indicates that it is in respect of holding of the shareholder named in 2 above or in respect of a non-beneficial interest or in the cast of an individual holder if it is a holding of that person’s spouse or children under the age of 18 or in respect of a non-beneficial interest

2 ABOVE

4. Name of the registered holder(s) and, if more than one holder, the number of shares held by each of them (if notified)

ROBERT MORRISSON ATWATER

5. Please state whether notification relates to a person(s) connected with the director named in 2 above and identify the connected person(s)

N/A

6. Please sate the nature of the transaction. For PEP transactions please indicate whether general/single co PEP and if discretionary / non discretionary

MARKET PURCHASE

7. Number of shares / amount of stock acquired

425,000

8. Percentage of issued class

0.33%

9. Number of shares / amount of stock disposed

N/A

10. Percentage of issued class

N/A

11. Class of security

ORDINARY SHARES OF 0.1 PENCE EACH

12. Price per share

10.00 PENCE

13. Date of transaction

20/12/04

14. Date company informed

20/12/04

15. Total holding following this notification

835,000

16. Total percentage holding of issued class following this notification

0.66%

17. Any additional information

N/A

18. Name of contact and telephone number for queries

MARK WARBURTON – 01625 505100

19. Name and signature of authorised company official responsible for making this notification

MARK WARBURTON – COMPANY SECRETARY

20. Date of Notification

21/12/04