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27 January 2006

Notification of substantial shareholding

Cyprotex PLC (AIM: CRX), announces that it received notification on 27 January 2006, that, as of the same date, Bank of Scotland has beneficially acquired 27,115,098 ordinary shares in the Company. This represents the total holding of Bank of Scotland in the capital of the Company and equates to 19.6% of the issued share capital.

For further information:

Cyprotex PLC
Robert Morrison Atwater, Chairman & Chief Executive Officer
Tel: +44 1625 505 100
ir@cyprotex.com
www.cyprotex.com

Media Enquires:

Heather Salmond / Chris Lane
Abchurch Communications
Tel: +44 (0) 20 7398 7700
chris.lane@abchurch-group.com
www.abchurch-group.com

News Contact:

Robert Morrisson Atwater, Chairman & CEO
+44 1625 505 152
ir@cyprotex.com
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