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Latest screening services | Packages | Compound screening
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  Delivers consistent, accurate compound data with cost-efficiency that comes from a degree of automation and high throughput liquid handling.
  • Highly reproducible, accurate data - validated and used by AstraZeneca, Solvay, Roche, and over 50 other Pharmaceutical and Biotechnology companies.

  • Delivery of data for core in vitro ADME and physicochemical assays is within 10 working days to fit in with the make-test timelines in drug discovery.

  • Highly cost effective due to our emphasis on high throughput engineering.

  • Attention to good quality customer care, with highly trained Principal Scientists on hand to explain results and suggest the most appropriate experimental strategy.
Cloe® Screen has passed evaluations by both large pharmaceutical and smaller biotechnology partners who now routinely use Cloe® Screen to support their drug discovery.

Cloe® Screen Services

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Cyprotex Mass Spectrometry
In vitro metabolism
Cytochrome P450 inhibition (IC50 determination)  
CYP3A4 Human liver microsomes
CYP2D6 Human liver microsomes
CYP2C19 Human liver microsomes
CYP1A2 Human liver microsomes
CYP2C9 Human liver microsomes
Cytochrome P450 mechanism-based inhibition  
CYP3A4 Human liver microsomes
CYP2D6 Human liver microsomes
CYP1A Human liver microsomes
CYP2C9 Human liver microsomes
CYP2C19 Human liver microsomes
Cytochrome P450 isoform identification  
CYP3A4 Recombinant enzyme bactosomes
CYP2D6 Recombinant enzyme bactosomes
CYP2C19 Recombinant enzyme bactosomes
CYP1A2 Recombinant enzyme bactosomes
CYP2C9 Recombinant enzyme bactosomes
Cytochrome P450 induction  
CYP3A4 & CYP1A2 now available under Cloe® Select
Metabolic Stability  
Microsomal stability range of species available
S9 stability range of species available
Plasma stability range of species available
Hepatocyte stability range of species available
Microsomal Binding range of species available
Metabolic profiling, identification and characterisation

now available under Cloe® Select
In vitro Permeability
MDR1-MDCK Permeability Transfected MDCK cell line
Wild Type MDCK Permeability Wild Type MDCK cell line
Caco-2 Permeability Caco-2 cells
PAMPA Parallel Artificial Membrane Permeation Assay
Solution Properties
Turbidimetric aqueous solubility Kinetic method, from DMSO solution
Thermodynamic solubility HPLC-UV method from solid
Log D Shake flask method
Lipophilicity (CHI) Chromatographic Hydrophobicity Index
Plasma Protein Binding Range of species available (10%, 50% or 100% plasma)
Log P, pKa determination now available under Cloe® Select
Chemical Stability  
Toxicity
hERG channel inhibition (IC50 determination) High throughput single cell planar patch clamp
PK and Bioanalysis

Can't see the assay you need?

Contact our Product Development Team with your requirements.

 
New assay:
Cloe® Select: P-gp inhibition assay
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