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Understanding compound exposure levels from in vitro data

Cloe® PK is a pharmacokinetic prediction system that integrates compound property data derived from in vitro ADME screening, QSAR predictive models or a combination of both. The input data that is required to predict a compound's exposure profile is limited to ADME properties that are typically generated in early discovery programs.

For predicting exposure levels from an intravenous administration:
  • Log P, Lipophilicity (CHI or Log D), pKa
  • Metabolic stability rate
  • Fraction unbound in plasma
For predicting exposure levels from an oral administration:
  • Log P, Lipophilicity (CHI or Log D), pKa
  • Metabolic stability rate
  • Fraction unbound in plasma
  • Solubility
  • Permeability (e.g. Caco-2 permeability)
New assay:
Cloe® Select: P-gp inhibition assay
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Request an information pack or ADME guide:
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