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Cloe® Screen Packages
We perform a package of Cloe® Screen assays that will collectively
deliver information to support decision making at various stages in
drug discovery. Typical packages are shown here or we will construct
tailored packages to address issues that are particular to our partners
projects.
Cloe® Screen/PK - in vitro ADME screening
and integration for pharmacokinetic prediction in human and rats
- Cloe® Screen in vitro ADME screening assays: human
and rat microsomal stability, human and rat plasma protein binding,
lipophilicity (CHI or logD shake flask), predicted pKa and logP,
turbidimetric aqueous solubility, Caco-2 permeability (apical
to basolateral).
- Cloe® PK pharmacokinetic prediction of venous plasma concentration/time
profile and all derived pharmacokinetic parameters for human and
rat oral and i.v.dosing.
Cloe® Screen Lead ID - early compound profiling
to select the best lead series to take forward into lead optimisation
- Cloe® Screen in vitro ADME screening assays: microsomal
stability, turbidimetric aqueous solubility, Caco-2 permeability
(apical to basolateral), cytochrome P450 inhibition (CYP3A4 IC50
determination)
Cloe® Screen Lead Optimisation - fast turnaround
data generation to support make-test decision making
- Cloe® Screen in vitro ADME screening assays: microsomal
stability, turbidimetric aqueous solubility, Caco-2 permeability
(bidirectional), cytochrome P450 inhibition (5 isoforms), hERG
channel inhibition (hERG automated patch clamp), plasma protein
binding
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