Products & Services

In vitro ADME screening service

Cloe® Screen is a cost-effective, high quality in vitro ADME screening service that delivers critical information on absorption (including Caco-2 permeability, PAMPA and MDR1-MDCK), distribution (including plasma protein binding), metabolism (including cytochrome P450 inhibition), excretion, toxicity (hERG using automated patch clamp techniques) and physicochemical properties for Pharmaceutical and Biotechnology companies.

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Bespoke ADME and DMPK experimental service

Cloe® Select is a high quality DMPK service designed to meet the requirements of later stage development projects. Cloe® Select includes: in vitro metabolism (cytochrome P450 induction, K_i determination and metabolite profiling and identification), in vitro permeability (P-glycoprotein inhibition), physicochemical properties (pKa and LogP) and pharmacokinetics and bioanalysis.

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Predictive modelling using QSAR and PBPK techniques

Cloe® Predict is a selection of predictive technologies designed to improve efficiency in the Drug Discovery Process. These include Cloe® PK - a novel system for predicting the pharmacokinetic properties of a drug in the body from physicochemical and in vitro ADME data; Cloe® Predict HIA for the prediction of human intestinal absorption using in vitro solubility, pKa and Caco-2 permeability data; and Cyprotex Discovery Bus – a novel software platform which automates human decision making with applications including auto QSAR and automation of laboratory workflow.

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