Screening and structural characterization of reactive metabolites, as one of the major efforts to reduce attrition in drug development, has increasingly become an integral part of the ADMET-guided lead optimization process in drug discovery.
2 Yan Z, Maher N, Torres R, Caldwell GW and Huebert N (2005) Rapid Commun Mass Spectrom 19; 3322-3330
1 Evans DC et al. (2004) Chem Res Toxicol 17(1); 3-16
2 Yan Z et al. (2005) Rapid Commun Mass Spectrom 19; 3322-3330