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Articles & White Papers

ADME

ADME Guide
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DDI Regulatory Guide
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Studying the right transporter at the right time an in vitro strategy for assessing drug drug interaction risk during drug discovery and development
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Metformin Mechanism of DDI
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HT-ADME in a contract research organization laboratory: can you ensure bioanalytical quality in a highly automated environment?
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Relating Caco-2 permeability to molecular properties using block relevance analysis
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Prediction of Phosphoglycoprotein (P-gp)-Mediated Disposition in Early Drug Discovery
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Challenges in the Prediction and Modelling of Oral Absorption and Bioavailability - 2010
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ADMET for Medicinal Chemists: A Practical Guide
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Simulation modelling of human intestinal absorption using Caco-2 permeability and kinetic solubility data for early drug discovery - 2008
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Determination of a human hepatic microsomal scaling factor for predicting in vivo drug clearance - 2006
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Outsourcing discovery ADME screening - 2003
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Toxicology

The evolution of strategies to minimise the risk of human drug induced liver injury (DILI) in drug discovery and development
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The Future of Microelectrode Array in Early Toxicology Assessment - March 2020
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Mechanisms of Drug-Induced Toxicity Guide
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Launch of the Alliance for Human Relevant Science
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A combined in vitro approach to improve the prediction of mitochondrial toxicants
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Evaluation of an In Vitro Human Dermal Sensitization Test for Use with Medical Device Extracts
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Using ToxCast™ Data to Reconstruct Dynamic Cell State Trajectories and Estimate Toxicological Points of Departure
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A comparison of microtissue formation using either ultra-low adhesion plates or hanging drop
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Horizon2020 project EU-ToxRisk
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Consumer Product Safety Testing - Infographic
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Types of Skin Sensitisation Assays: Comparison Sheet
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Predicting Respiratory Toxicity Using a Human 3D Airway (EpiAirwayTM) Model Combined with Multiple Parametric Analysis
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The contribution of physicochemical properties to multiple in vitro cytotoxicity endpoints
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In silico

Pharmacometrics Markup Language (PharmML): Opening New Perspectives for Model Exchange in Drug Development
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Cross-validation pitfalls when selecting and assessing regression and classification models
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In Silico Models of Drug Metabolism and Drug Interactions
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Clinical relevance of predictive physiologically based pharmacokinetic methods - 2008
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Integrating in vitro ADMET data through generic physiologically based pharmacokinetic models - 2006
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Application of a generic physiologically based pharmacokinetic model to the estimation of xenobiotic levels in human plasma - 2006
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Application of a generic physiologically based pharmacokinetic model to the estimation of xenobiotic levels in rat plasma - 2006
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Automated QSPR through competitive workflow - 2005
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Cloe® PK White Paper - 2004
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Virtual humans for pharmacokinetics - 2004
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