The Cyprotex blog discusses the issues faced by companies in the pharmaceutical, personal care, cosmetics and chemical industries. We highlight innovations, reflect on industry news and developments, discuss regulations and connect with scientists.
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- ADME PK
- ADME PK
- In Vitro Metabolism
- In Vitro Metabolism overview
- Reaction Phenotyping
- Cytochrome P450 Induction
- Cytochrome P450 Inhibition
- Cytochrome P450 Ki
- Hepatocyte Stability
- Low Clearance Hepatocyte Stability
- Hepatic Uptake Assay
- Metabolite Profiling and Identification
- Plasma Stability
- Microsomal Stability
- Microsomal Binding
- S9 Stability
- Time Dependent Inhibition (single point)
- Time Dependent Inhibition (IC50 Shift)
- Time Dependent Inhibition (kinact/KI )
- PXR and AhR Nuclear Receptor Activation
- UGT Inhibition
- In Vitro Permeability and Transporters
- In Vitro Permeability and Transporters overview
- Caco-2 Permeability
- PAMPA
- MDR1-MDCK Permeability
- MDCK (wild type) Permeability
- P-glycoprotein Inhibition
- BCRP Substrate Identification
- BCRP Inhibition Assay
- SLC Transporter Substrate Identification
- SLC Transporter Inhibition
- BSEP Inhibition
- Transporter Knockout Assays
- Polymorphic and Non-CYP Mediated Metabolism
- Protein Binding
- Bioanalysis
- High Throughput ADME
- DDI Packages
- Prodrug Services
- Toxicology
- Toxicology
- Neurotoxicity
- Nephrotoxicity
- Multiparametric Toxicity
- Cardiotoxicity
- Mechanistic Toxicity
- Mechanistic Toxicity overview
- Phospholipidosis and Steatosis
- Lysosomal Trapping
- Hemolysis
- Mitochondrial Toxicity (Glu/Gal Assay)
- Functional Mitochondrial Toxicity Assay (Seahorse XFe96)
- DILIsym collaboration
- Reactive Metabolite
- Toxicological Gene Regulation
- Cell Viability
- KeratinoSens™ Skin $Sensitisation$
- Androgen Receptor Modulation
- Phototoxicity
- 3D Microtissue Models
- Genotoxicity
- Drug-Drug Interactions
- Non-GLP Exploratory Toxicology
- $Customised$ Toxicology Service
- Biosciences
- In Silico
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