The Cyprotex blog discusses the issues faced by companies in the pharmaceutical, personal care, cosmetics and chemical industries. We highlight innovations, reflect on industry news and developments, discuss regulations and connect with scientists.
- Home
- Home
- ADME PK
- ADME PK
- In Vitro Metabolism
- In Vitro Metabolism overview
- Reaction Phenotyping
- Cytochrome P450 Induction
- Relative Induction Score
- Cytochrome P450 (CYP) Inhibition (IC50)
- Cytochrome P450 Inhibition (Ki)
- Hepatocyte Stability
- Low Clearance HµREL Co-culture
- Low Clearance Hepatocyte Stability
- Hepatic Uptake Assay
- Metabolite Profiling and Identification
- Plasma Stability
- Microsomal Stability
- Microsomal Binding
- S9 Stability
- Time Dependent CYP Inhibition (single point)
- Time Dependent CYP Inhibition (IC50 shift)
- Time Dependent CYP Inhibition (kinact/KI )
- PXR and AhR Nuclear Receptor Activation
- UGT Inhibition
- In Vitro Permeability and Transporters
- In Vitro Permeability and Transporters overview
- PAMPA
- Caco-2 Permeability
- MDCK-MDR1 Permeability
- P-gp Substrate Identification
- BCRP Substrate Identification
- Human SLC Transporter Substrate Identification
- Human MRP Transporter Substrate Identification
- Preclinical Hepatic Oatp Substrate Identification
- P-glycoprotein Inhibition
- BCRP Inhibition
- Human SLC Transporter Inhibition
- BSEP, MRP2, MRP3 and MRP4 Inhibition
- Preclinical Hepatic Oatp Transporter Inhibition
- Polymorphic and Non-CYP Mediated Metabolism
- Protein Binding
- Bioanalysis
- High Throughput ADME
- DDI Packages
- Prodrug Services
- Toxicology
- Toxicology
- 3D Microtissue Models
- Mitochondrial Toxicity
- Multiparametric Toxicity
- Hepatotoxicity and Drug-induced Liver Injury (DILI)
- Hepatotoxicity and Drug-induced Liver Injury (DILI) overview
- CellCiphr® Premier
- Genotoxicity
- Transcriptomics Services
- Mitochondrial Toxicity
- Cytochrome P450 Time Dependent Inhibition (IC50 Shift)
- Reactive Metabolite Assessment
- BSEP, MRP2, MRP3 and MRP4 Inhibition
- Lysosomal Trapping
- Drug Induced Phospholipidosis & Steatosis Assay
- Cytotoxicity Screening Panel
- 3D Hepatotoxicity Assay using HepaRG Spheroids
- Genotoxicity
- Mechanistic Toxicity
- Mechanistic Toxicity overview
- Cell Stress Panel
- Apoptosis and Necrosis Assay (Flow Cytometry)
- Phospholipidosis and Steatosis
- Lysosomal Trapping
- Hemolysis
- DILIsym collaboration
- Reactive Metabolite
- Toxicological Gene Regulation
- Cell Viability
- KeratinoSens™ Skin $Sensitisation$
- Androgen Receptor Modulation
- Phototoxicity
- Cardiotoxicity
- Neurotoxicity
- Nephrotoxicity
- Drug-Drug Interactions
- Non-GLP Exploratory Toxicology
- $Customised$ Toxicology Service
- In Silico
- Physicochemical Profiling
- About
- Services
- Services
- ADME PK
- ADME PK
- In Vitro Metabolism
- In Vitro Metabolism overview
- Reaction Phenotyping
- Cytochrome P450 Induction
- Relative Induction Score
- Cytochrome P450 (CYP) Inhibition (IC50)
- Cytochrome P450 Inhibition (Ki)
- Hepatocyte Stability
- Low Clearance HµREL Co-culture
- Low Clearance Hepatocyte Stability
- Hepatic Uptake Assay
- Metabolite Profiling and Identification
- Plasma Stability
- Microsomal Stability
- Microsomal Binding
- S9 Stability
- Time Dependent CYP Inhibition (single point)
- Time Dependent CYP Inhibition (IC50 shift)
- Time Dependent CYP Inhibition (kinact/KI )
- PXR and AhR Nuclear Receptor Activation
- UGT Inhibition
- In Vitro Permeability and Transporters
- In Vitro Permeability and Transporters overview
- PAMPA
- Caco-2 Permeability
- MDCK-MDR1 Permeability
- P-gp Substrate Identification
- BCRP Substrate Identification
- Human SLC Transporter Substrate Identification
- Human MRP Transporter Substrate Identification
- Preclinical Hepatic Oatp Substrate Identification
- P-glycoprotein Inhibition
- BCRP Inhibition
- Human SLC Transporter Inhibition
- BSEP, MRP2, MRP3 and MRP4 Inhibition
- Preclinical Hepatic Oatp Transporter Inhibition
- Polymorphic and Non-CYP Mediated Metabolism
- Protein Binding
- Bioanalysis
- High Throughput ADME
- DDI Packages
- Prodrug Services
- Toxicology
- Toxicology
- 3D Microtissue Models
- Mitochondrial Toxicity
- Multiparametric Toxicity
- Hepatotoxicity and Drug-induced Liver Injury (DILI)
- Hepatotoxicity and Drug-induced Liver Injury (DILI) overview
- CellCiphr® Premier
- Genotoxicity
- Transcriptomics Services
- Mitochondrial Toxicity
- Cytochrome P450 Time Dependent Inhibition (IC50 Shift)
- Reactive Metabolite Assessment
- BSEP, MRP2, MRP3 and MRP4 Inhibition
- Lysosomal Trapping
- Drug Induced Phospholipidosis & Steatosis Assay
- Cytotoxicity Screening Panel
- 3D Hepatotoxicity Assay using HepaRG Spheroids
- Genotoxicity
- Mechanistic Toxicity
- Mechanistic Toxicity overview
- Cell Stress Panel
- Apoptosis and Necrosis Assay (Flow Cytometry)
- Phospholipidosis and Steatosis
- Lysosomal Trapping
- Hemolysis
- DILIsym collaboration
- Reactive Metabolite
- Toxicological Gene Regulation
- Cell Viability
- KeratinoSens™ Skin $Sensitisation$
- Androgen Receptor Modulation
- Phototoxicity
- Cardiotoxicity
- Neurotoxicity
- Nephrotoxicity
- Drug-Drug Interactions
- Non-GLP Exploratory Toxicology
- $Customised$ Toxicology Service
- In Silico
- Physicochemical Profiling
- Unique Technologies
- Publications/Guides
- Events
- News
- Blog
- Investor
- Contact
- Careers
