Certain drugs impair bile acid export, which can lead to intrahepatic accumulation and cause drug-induced cholestasis. Bile […]
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- ADME PK
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- In Vitro Metabolism
- In Vitro Metabolism overview
- Reaction Phenotyping
- Cytochrome P450 Induction
- Relative Induction Score
- Cytochrome P450 (CYP) Inhibition (IC50)
- Cytochrome P450 Inhibition (Ki)
- Hepatocyte Stability
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- Hepatic Uptake Assay
- Metabolite Profiling and Identification
- Plasma Stability
- Microsomal Stability
- Microsomal Binding
- S9 Stability
- Time Dependent CYP Inhibition (single point)
- Time Dependent CYP Inhibition (IC50 shift)
- Time Dependent CYP Inhibition (kinact/KI )
- PXR and AhR Nuclear Receptor Activation
- UGT Inhibition
- In Vitro Permeability and Drug Transporter Services
- In Vitro Permeability and Drug Transporter Services overview
- PAMPA
- Caco-2 Permeability
- MDCK-MDR1 Permeability
- P-gp Substrate Identification
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- Human SLC Transporter Substrate Identification
- Human MRP Transporter Substrate Identification
- Preclinical Hepatic Oatp Substrate Identification
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- Human SLC Transporter Inhibition
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