Latest Scientific Advancements Presented at ADME-Tox Lead Optimisation Workshop

On Dec 6th, approximately 120 ADME-Tox experts gathered for Cyprotex’s ADME-Tox Lead Optimization Workshop at the DoubleTree Suites in Boston, USA.

Executive Vice President of ADME-Tox and DMPK of the Evotec Group, Dr Rob Riley, opened the event by presenting the key challenging facing the industry in the field of ADME-Tox.  During the workshop, scientific leaders from Genentech, Pfizer, BMS, Takeda, Celgene, Sage Therapeutics and Cyprotex presented on a range of key topics in ADME-Tox. Predicting in vivo outcome from in vitro ADME-Tox data was a constant theme throughout the day with different strategies being presented based on real case studies within the pharmaceutical industry.

Speakers and topics are listed below:

Will Proctor (Associate Director, Investigative Toxicology, Genentech, Inc): Assessing Hepatotoxicity Risk in Drug Discovery: Practical Strategies and Decision Making During Lead Optimization.

Ganesh Rajaraman (Associate Director, DMPK, Celgene): Is There a DMPK Framework for LARGE Small Molecules (bRO5)?

Qin Wang (Scientist, Investigative Toxicology, Takeda Pharmaceuticals): Exploring the Utility of 3D Cortical Spheroids in the Detection of CNS Toxicity

Rui Li (Principal Scientist, Pharmacokinetic and Pharmacodynamic Modelling, Pfizer): Pharmacokinetics of OATP Substrates – Predicting Liver Exposure Based on Systemic Exposure.

Matt Soars (Director, Head of PCO Cambridge, MA, Bristol-Myers Squibb): Discovery and Characterization of a Novel PDL1 Millamolecule.

Chris Strock (Associate Director, Biological Screening and Assay Development, Cyprotex US, LLC): Developing MEA and High Content Assays for Prediction Based on Organ Specific Cellular Subtypes

Allen Hopper (Director Exploratory Research, Sage Therapeutics): Aldehyde Oxidase and Impacts in Drug Discovery

Adam Brockman (Director of Operations, Cyprotex US, LLC): Automated in vitro ADME-Tox Testing to Facilitate Efficient Lead Optimization

The popularity of these workshops continues to grow. Cyprotex are committed to knowledge sharing within the scientific community and these educational events offer an arena for learning about the latest research in the field as well as a forum for discussion and sharing of ideas. Similar ADME-Tox focused events are planned on the West Coast and in the UK for 2019.

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