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chemPK™ is a workflow-based solution that predicts human pharmacokinetic parameters directly from chemical structure using a PBPK modeling approach. It predicts blood (or plasma) and tissue time-concentration profiles following oral and intravenous dosing regimens (for single and repeat doses).
chemTox is a workflow-based solution that predicts key toxicity parameters such as Ames mutagenicity and rat acute dose LD50 as well as aqueous solubility directly from chemical structure.
chemTarget is a virtual screening tool that predicts biological target interaction (e.g., binding affinity) directly from chemical structure. It can also be used in conjunction with chemPK™ to predict in vivo target engagement.
DDI-Fusion is a workflow-based solution which combines in vitro data with chemical structure to predict human DDI.
Cloe® PK is an innovative software system that uses PBPK in silico modeling for pharmacokinetic simulation. The software integrates ADME and physicochemical data to simulate drug exposure and duration of drugs in blood, major tissues and organs as well as the prediction of key parameters such as absorption, clearance, half-life, volume of distribution and bioavailability.
Cloe® HIA is a reliable physiological model which uses a combination of solubility, pKa and Caco-2 permeability data for the prediction of human intestinal absorption of an orally administered compound.
The Cyprotex Discovery Bus is a novel and powerful software platform designed to enhance efficiency in drug discovery by automating human decision making and information handling using intelligent workflow. Applications include auto QSAR and automation of laboratory workflow processes.
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