A tool for integrating in vitro ADME and phys-chem data to simulate dose dependent absorption in the GI tract.
A simple set of early ADME and physicochemical data is required to run a Cloe HIA prediction as detailed below. Either measured or predicted values can be used.
|Data requirements for Cloe HIA|
Predictions are generated in a downloadable pdf report and Excel spreadsheet with interactive sensitivity analysis capability.
The following parameters are reported.
Cloe HIA uses physiological modeling to integrate Caco-2 permeability and phys-chem data. It models transit of fluid (containing dissolved and undissolved compound), gastric, biliary and pancreatic secretion and absorption in five segments of the GI tract.
|Gaining access to Cloe HIA|
|Cyprotex can run Cloe HIA predictions on your behalf. You can either send us your data or we can generate data for you via our in vitro ADME or phys-chem services. Assistance in interpreting the data is included in this service.|
Contact firstname.lastname@example.org for a demo
Thomas S et al. (2008) J. Pharm. Sci 97; 4557-74
Cloe®is a registered trademark owned by Cyprotex PLC