A tool for integrating in vitro ADME data to predict plasma and organ pharmacokinetics
Data requirements for intravenous dosing |
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Data requirements for oral dosing |
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Predictions are delivered automatically in a downloadable pdf report and Excel spreadsheet with interactive sensitivity analysis capability.
The following parameters are reported:
• Concentration time profiles in venous and arterial plasma.
• Concentration time profiles in 14 organs and tissues.
• Summary pharmacokinetic parameters
Additional Features |
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Cloe PK integrates ADME data derived from experimental assays or QSAR predictive models using PBPK modeling techniques. The input data are limited to ADME and physicochemical properties that are typically generated in early drug discovery programs.
Prediction accuracy and compound ranking closely correlates with human clinical data and animal experiments.
Gaining Access to Cloe PK |
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Cyprotex can run Cloe PK predictions on your behalf. You can either send us your data or we can generate data for you via our in vitro ADME and phys-chem services. Assistance in interpreting the data is included in this service. |
Contact enquiries@cyprotex.com for more information.
Cloe® is a registered trade mark owned by Cyprotex PLC