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Posters

ADME

Echo MS in High Throughput ADME - EBF 2022

Application of Ultra-fast LC-MS/MS in DMPK Screening - EBF 2022

Comparing Basic Static Models for Predicting Clinical CYP3A4 Induction Risk DMDG 2022

Characterization of Selective CYP46A1 Inhibitors and Activators AAPS 2022

Development of a High-Throughput Time Dependent Inhibition of CYP450 Assay in Cyropreserved Human Hepatocytes

Gold Standard Plasma Protein Binding DMDG EC 2022

A High Throughput Assay for Determining Aqueous Solubility DMDG EC 2022

Time Point Sampling Methodology HuREL DMDG EC 2022

Application of Acquity Premier Technology for Enhanced Chromatographic Performance DMDG EC 2022

Caco-2 and MDCK-MDR1 In Vitro Permeability Assay Efficiencies DMDG EC 2022

Evaluation of HμREL® Co-culture for Low Clearance Assessment

Improving Compound Recovery of Lipophilic Bases in the Low Clearance Metabolic Stability Assay using HµREL ® Co-culture

Application of Mass Defect Filtering - BMSS 2019

Use of Stable Labelled Glutathione as an Additional Diagnostic Tool - HT-ADME 2021

Determining CHI using LC-TTOF - HT-ADME 2021

Use of HµREL® Co-Culture Model for Low Clearance - ISSX 2019

Application of Ultra-fast LC-MS to High Throughput Screening Assays in ADME_Discovery-HT-ADME_2019

Investigation of Inhibitor on Human OATP1B1, P-gp and BCRP In Vitro Inhibitory Potencies

Application of a Low Clearance Assay in Preclinical Drug Discovery

GCMS assessment of chemicals for ADME assessment

Estrone 3-Sulfate as a Surrogate Breast Cancer Resistance Protein (BCRP) in vitro Probe Substrate for assessing Drug-Drug Interaction Risk with Rosuvastatin

Toxicology

Validation of a Serum-Free Approach to Facilitate the Development of HT Immunogenicity Screening - SOT 2023

Optimization of Rat Neurite Outgrowth Assay for Peripheral Neuropathy Prediction - SOT 2023

Use of LEAP Determined with MEA to Enhance Prediction of Cardiotoxicity - SOT 2023

HC Imaging for Detection of Compound Reactive Metabolite Formation and Cardiotoxicity - SOT 2023

HC Screening and HT RNA Sequencing using hiPSC-CMs for Cardiotoxicity - SOT 2023

High-content screening and HT-RNA sequencing using hiPSC CMs ICT 2022

Evaluating Functional and Structural Cardiotoxicants using Calcium Flux, HCI and High Throughput Transcriptomics

High Throughput RNA-Seq Profiling of 3D Liver Organoids to Predict Drug-Induced Liver Injury (DILI)

Development of In Vitro Assays to Predict Potential Immunotoxicological Liabilities of Candidate Drugs using Human Peripheral Blood Mononuclear Cells

Identifying Seizures with MEA: Complementary Human and Rat Neuronal Models Enhance Predictivity

Comprehensive In Vitro Approach to Gain Insights into Mechanisms of Mitochondrial Toxicity- Eurotox 2021

Multiplexed In Vitro Approach for Dual Detection of Functional and Structural Cardiotoxicity - Eurotox 2021

Assessing the Differential Sensitivities of MEA vs Neurite Outgrowth for Detecting CNS Liabilities-SOT 2020

Evaluating the Effects of the Muscarinic Receptor Agonist Pilocarpine on Neural Network Activity-SOT2019

Evaluation of Pilocarpine in Multiple Neuronal Cell Types Using Microelectrode Array - SPS 2018

A combined in vitro approach for the dual detection of functional and structural cardiotoxicity

Comprehensive Approach using in vitro Assays to Detect and Identify Mechanism of Mitochondrial Toxicity_European WPC 2018

Utilization of Human iPSC-Derived Cardiomyocytes on an MEA Platform for Prediction of Liabilities with Chronic Drug Treatment_SPS_2018

A Comprehensive Comparison of In Vitro Assays Utilised to Detect Mitochondrial Toxicity

Cardiac Microtissue Models to Determine Functional and Structural Cardiotoxicants

Gaining Insights into Mechanism of Mitochondrial Toxicity Using a Comprehensive Approach of In Vitro Assays - Eurotox 2019

TAK875 - Investigating DILI utilising in vitro Mechanistic Assays

Chronic Multiplatform Assay to Evaluate Cardiotoxicity of BMS-986094 in iPSC-Derived Human Cardiomyocytes

Human 3D Liver Models with Multiparametric Cell Health Approaches for Prediction of DILI

Cardiotoxicity Evaluation of Chronic BMS-986094 Exposure in Human iPSC-Derived Cardiomyocytes

Evaluating the Pharmacology and Neurotoxic Predictability of Neuroactive Compounds

Multiparametric in vitro Toxicity Approaches to Understand the Hepatotoxic Mechanism of Action of Fasiglifam

A high content screening approach to genotoxicity testing for aneugens and clastogens

Multiparametric in vitro toxicity approaches to determine hepatotoxic mechanism

Human Induced Pluripotent Stem Cell-derived Glutamatergic Neurons: Evaluating Maturation and Neurotoxic Predictability in the Presence or Absence of GABAergic Neurons and Astrocytes Using a Microelectrode Array Platform

3D Microtissue Poster - NC3R May 2017

Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation in TAK-875-induced Liver Injury

Evaluating the Arrhythmic Potential of Vanoxerine in Human iPSC Derived Cardiomyocytes on a Multiwell MEA

Predicting DILI using multi-donor type human liver microtissues(hLiMTs), confocal high content screening (HCS) data and normalisation to therapeutically relevant tissue specific concentrations (ts_Cmax)

Kidney in vitro models for the improved prediction of chemical-induced nephrotoxicity

Development of a Model for Assessment of Blue Light Activated Toxicity in EpiGingival and EpiGingival-FT Tissues

Cardiac microtissue models for the improved prediction of drug induced cardiac hypertrophy

Assessment of the Biocompatibility of Various Bone Graft Substitutes Using Primary Human Osteoblasts and Mesenchymal Stem Cells Isolated from Bone Marrow

In silico

PKPD_Modelling_of Antibiotic_Efficacy-Alderley_Park_3Rs_Poster_Event

PBPK Modelling for Predicting Human PK in Drug Discovery

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