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Posters

A Comprehensive Comparison of In Vitro Assays Utilised to Detect Mitochondrial Toxicity
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Investigation of Inhibitor on Human OATP1B1, P-gp and BCRP In Vitro Inhibitory Potencies
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Cardiac Microtissue Models to Determine Functional and Structural Cardiotoxicants
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TAK875 - Investigating DILI utilising in vitro Mechanistic Assays
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Chronic Multiplatform Assay to Evaluate Cardiotoxicity of BMS-986094 in iPSC-Derived Human Cardiomyocytes
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Human 3D Liver Models with Multiparametric Cell Health Approaches for Prediction of DILI
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In vitro Characterization of Oral Absorption of Non-Pharmaceutical Chemicals
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Application of a Low Clearance Assay in Preclinical Drug Discovery
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Cardiotoxicity Evaluation of Chronic BMS-986094 Exposure in Human iPSC-Derived Cardiomyocytes
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Evaluating the Pharmacology and Neurotoxic Predictability of Neuroactive Compounds
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Multiparametric in vitro Toxicity Approaches to Understand the Hepatotoxic Mechanism of Action of Fasiglifam
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A high content screening approach to genotoxicity testing for aneugens and clastogens
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Multiparametric in vitro toxicity approaches to determine hepatotoxic mechanism
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GCMS assessment of chemicals for ADME assessment
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PBPK Modelling for Predicting Human PK in Drug Discovery
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Estrone 3-Sulfate as a Surrogate Breast Cancer Resistance Protein (BCRP) in vitro Probe Substrate for assessing Drug-Drug Interaction Risk with Rosuvastatin
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3D Microtissue Poster - NC3R May 2017
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Human Induced Pluripotent Stem Cell-derived Glutamatergic Neurons: Evaluating Maturation and Neurotoxic Predictability in the Presence or Absence of GABAergic Neurons and Astrocytes Using a Microelectrode Array Platform
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Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation in TAK-875-induced Liver Injury
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Evaluating the Arrhythmic Potential of Vanoxerine in Human iPSC Derived Cardiomyocytes on a Multiwell MEA
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Predicting DILI using multi-donor type human liver microtissues(hLiMTs), confocal high content screening (HCS) data and normalisation to therapeutically relevant tissue specific concentrations (tsCmax)
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Kidney in vitro models for the improved prediction of chemical-induced nephrotoxicity
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Development of a Model for Assessment of Blue Light Activated Toxicity in EpiGingival and EpiGingival-FT Tissues
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Cardiac microtissue models for the improved prediction of drug induced cardiac hypertrophy
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Assessment of the Biocompatibility of Various Bone Graft Substitutes Using Primary Human Osteoblasts and Mesenchymal Stem Cells Isolated from Bone Marrow
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High Throughput Screening-ADME-Tox; Transitioning from Triple Quadrupole to High Resolution Accurate Mass Spectrometry
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3D Multiplexed High Content Screening HCS of Human Derived Microtissue Models for the Improved in vitro Prediction of Toxicity
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Confocal High Content Screening of Cardiac and Liver Microtissues for the Improved Prediction of Drug Induced Toxicity
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CON4EI: Short Time Exposure (STE) Model
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Predicting neurotoxicity of the brain by normalising 3D multiplexed high content screening (HCS) data to brain tissue specific exposure levels
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Predicting drug-induced liver injury by normalising liver microtissue high content screening data to in vivo tissue concentrations.
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The roles of disposition and pharmacokinetics in determining drug tolerability: a virtual approach using QSPR and PBPK modelling
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Virtual pharmacokinetic prediction for compound selection in early drug discovery
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Development and integration of the WinBUGS connector in the DDMoRe Interoperability Framework
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Use of allopurinol-free cytosolic preparations in the study of aldehyde oxidase and xanthine oxidase mediated metabolism
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Estrone 3-Sulfate as a Surrogate Breast Cancer Resistance Protein BCRP In Vitro Probe Substrate for Predicting Drug-Drug Interaction Potential with Rosuvastatin
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Utilisation of 3D cardiac microtissues for the improved prediction of drug induced structural cardiotoxicity and cardiac hypertrophy
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Evaluation of an In Vitro Human Dermal Sensitization Test for Use with Medical Device Extracts
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Methods of In vitro Skin Metabolism Assessment
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The potential of hLiMTs and HepaRG spheroids to improve the in vitro prediction of drug-induced liver injury (DILI) using a repeat dose high content screening (HCS) approach
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Further Investigation of the Impact of Inhibitor Pre-Incubation on Human OATP1B1, OAT3, OCT2 and MATE1 Transporter In Vitro Inhibitory Potencies
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The combination of measuring oxygen consumption and extracellular acidification with the Glu/Gal assay improves the detection of mitochondrial toxicants
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Human Stem Cell-Derived Neurons for Neurotoxicity Functional Screens
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Confocal high content screening of cardiac microtissues for the improved prediction of drug induced structural cardiotoxicity
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Development of a Multiplatform Assay Using High Content Screening and Microelectrode Array to Assess Cardio, Neuro, and Hepato-Toxicity in a Group of Antipsychotic Drugs
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A High Throughput High Content Screen for the Detection of Androgen Receptor Modulators
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Detection of drug cholestatic potential using confocal high content screening in HepaRG and human liver microtissues (hLiMTs)
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Using the Short Time Exposure (STE) and Eye Irritation Test (EIT) for Full GHS Categorization of Ocular Irritation
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Impact of Blood Collection Method on Human Plasma Protein Binding for Compounds Preferentially Binding to α1–Acid Glycoprotein
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An in silico model to predict renal clearance of xenobiotics in humans
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A high content screening (HCS) approach for predicting structural cardiotoxicity using spontaneously beating 3D cardiac microtissues
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Improved detection of mitochondrial toxicants using oxygen consumption and extracellular acidification rate in comparison to the Glu/Gal assay
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3D In Vitro Human Small Intestinal Tissue Models to Assess Drug Toxicity and Permeation
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In vitro Assessment of Skin Metabolism: Comparison of Methods and Implications for Wider Application
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Combination of Cheminformatics and In Vitro Assays to Predict Skin Sensitization Potential and Potency
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Impact of inhibitor pre-incubation on human OATP1B1, OAT3, OCT2 and MATE1 transporter in vitro inhibitory potencies
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In vitro assessment of drug-induced seizure liability using a multi-electrode array based rat cortical neuronal assay
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A novel high-throughput in vitro and multivariate spike train analysis platform for drug neurotoxicity and method of action identification
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A High Throughput MEA Assay Utilizing Rat Cortical Neurons Can Detect Both Glycine Receptor and GABAA Receptor Seizure Responses in Brucine
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Statistical Modeling of DILI Prediction for a Multiplexed HCS Toxicity Assay
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Evaluation of an In Vitro Human Dermal Sensitization Test for Use With Medical Device Extracts
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Development, Optimization and Standardization of an in vitro Skin Irritation Test for Medical Devices Using the Reconstructed Human Tissue Model EpiDerm
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HT Caco-2 permeability: the dominant role played by solutes’ hydrogen bonding donor properties
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Functional understanding of mitochondrial toxicants using the XFe96 flux analyser
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Comparison and combination of in silico and in vitro skin sensitization assays to predict skin sensitization potential and potency
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Validated UGT inhibition assays to assess potential drug-drug interaction liability of new chemical entities
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In vitro screening of non-CYP phase I metabolism- Assessment of AKRs - ISSX 2014
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An Improved In Vitro Method for Determining Chemical Effects on Steroidogenesis Using LC/MS/MS to Monitor Multiple Steroid Hormones Combined with Gene Expression
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Application of a New In vitro Sensitization Assay for the Evaluation of Medical Device Extracts
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Assessment of an In vitro Human Vaginal Epithelial Model for Predicting Vaginal Irritation
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Cell Specific Control of Estrogen Response Mechanisms in HeLa-9903 and T47D-KBluc Cell Lines
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Predicting Photosensitization Using an In Vitro Method
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Predicting Respiratory Sensitization Using Activation of Nrf2/ARE Genes in a Human Reconstructed Airway Model
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Challenges in the development of in vitro screens for assessing non-CYP mediated metabolism
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Use of Physiologically-based Pharmacokinetic modeling (PBPK) in conjunction with CellCiphr™ HCS to predict compound safety thresholds and improve lead optimization
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Utility of Different Test Systems for Determinig Carboxylesterase Substrate Specificity and Inhibition Potential
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Development of an in vitro Multiwell Multielectrode Array (MEA) Neurotoxicity Assay with Human iPS Derived Neurons
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Development of an in vitro Multiwell Cardiovascular Multielectrode Array (MEA) Toxicity Assay with Human iPS Cell Derived Cardiomyocytes
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Comparison of Chemical Inhibitors versus Genetic Knockout Cell Models for Identification of Pgp and BCRP Substrates in Caco-2 Cell Lines
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Potential Cholestatic Compounds Assessed by Membrane Transport Vesicle Assays as well as Bile Canaliculi Inhibition in Primary Human Hepatocytes
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Evaluation of High Content Mechanism Screening as a Prediction Tool for Organ Toxicity
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In vitro Assessment of Non-Cyp Mediated Metabolism
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Comparison of in silico and two in vitro high content screening approaches, phospholipidosis and lysosomal trapping, in predicting in vivo phospholipidosis
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Comparison of in silico and two in vitro high content screening approaches, phospholipidosis and lysosomal trapping, in predicting in vivo phospholipidosis
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An In vitro Screening Method to Evaluate the Drug-Drug Interaction Due to Inhibition of Sulfotransferase Enzymes (SULTS)
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Development of an LC-MS/MS Screening Method to Evaluate the Impact of Drugs on Cortisol Biosynthesis in Vitro
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Methods for Improving In Vitro Prediction of Intrinsic Clearance Utilising 3D Cell Culture Models
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Evaluation of Species and Tissue-Dependent Differences Observed in Carboxylesterase Metabolism Application to Pro-Drug Studies
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BSEP and MRP2 Transport Vesicle Screening Assays for the Prediction of Potential Cholestatic and Drug-Induced Liver Injury
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Utlizing Two High Content Screening Assays; HCS-phospholipidosis and HCS-lysosomal Trapping and In Silico Modelling Approaches in Predicting In Vivo Phospholipidosis
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eCiphrNeuro: A High Throughput Assay to Detect Neurotoxic Compounds in Early Drug Discovery
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Screening for EADs and pro-arrhythmic potential with human iPS derived cardiomyocytes using a multiwell Microelectrode Array (MEA)
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Carrageenan is Not a Ligand for Toll-Like-Receptor 4 (TLR4) in a Human Embryonic Kidney (HEK) Cell Model
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In vivo extrapolation of in vitro drug-induced hepatocyte accumulation of triglycerides to predict steatosis in rodents and humans
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Identification of proarrhythmic potential with IPS derived cardiomyocytes using a multiwell Microelectrode Array (MEA)
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Combining two high content screening approaches measuring phospholipidosis and lysosomal trapping with in silico modelling approaches to predict phospholipidosis occurrence in humans
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Approaches to Understanding the Impact of Blood Partitioning in Drug Discovery, ISSX 2011
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Evaluation of non-CYP Mediated Metabolism: Comparison of Recombinant Enzymes and Sub-cellular Fractions in Identifying non-CYP Mediated Pathways, ISSX 2011
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gADME(TM): Characterization of CYP2D6 Activity of Mutant Proteins using Control Substrates and CNS-active Drugs, ISSX 2011
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Characterization and Evaluation of In vivo/Ex vivo Inhibition of Monoamine Oxidase Enzymes Activities in Rat to Support Proof-of-Concept (POC) Studies of the New Generation of Monoamine Oxidase Inhibitors, ISSX 2011
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Comparison of Different Cell Models in High Content Screening to Investigate Metabolism-Mediated Hepatoxicity, SOT 2011
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Mechanistic Insight and Sensitivity of High Content Screening (HCS) over the Single Parameter MTT Assay, SOT 2011
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Comparison of the Effect of Assay Conditions on Interpretation of Time Dependent Inhibition of Cytochrome P450 Enzymes, SOT 2011
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Comparison of Chemical Inhibitors versus Genetic Knock-Out Cell Models for Identification of PGP and BCRP Substrates in Caco-2 Cell Lines for Evaluation of Transporter Based Drug-Drug Interactions
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9th International ISSX 2010 Meeting Poster - Evaluation Of Single Point And IC50 Shift Assays For Measuring Time-Dependent Inhibition Of Drug Discovery Compounds
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9th International ISSX 2010 Meeting Poster - In Vitro Evaluation Of P-gp, BCRP And MRP2 In Caco-2 Cells Using Probe Substrates And Inhibitors
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9th International ISSX 2010 Meeting Poster - Evaluation of Cryopreserved, Differentiated HepaRG Cells for the Simultaneous Determination of CYP450 Induction and Metabolism
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NITD TB Symposium 2010 Meeting Poster - Predicting the pharmacokinetics of drugs used in tuberculosis therapy
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Filtering Toxicity from the Pipeline: The Role of HCS in Early Identification of Toxic Liabilities, Eurotox 2011
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Comparison of In Vitro Cellular Approaches Using High Content Screening to Investigate Metabolism-Mediated Hepatotoxicity
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ELRIG SBS Drug Discovery 2010 Meeting Poster - In Vitro Models of Mechanisms of Human Toxicity: Validation and Application for Environmental and Developmental Toxicology
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SOT 2009 Conference Poster: Development of more bioavaliable orally absorbed chemopreventive agents from leads derived from natural sources: Potential challenges
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AAPS Drugs Transporters in ADME Workshop 2009: In vitro evaluation of P-glycoprotein inhibition using Loperamide as a probe substrate
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DDT 2007 Conference poster: Combination of in vitro Caco-2 and aqueous solubility screens with in silico physiological modelling for the prediction of human intestinal absorption in early drug discovery
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SBS 2007 Conference poster: Cloe® Screen MDR1-MDCK: A predictive model of human intestinal absorption and blood brain barrier permeability
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SBS 2007 Conference poster: Development of a high throughput assay for the screening of mechanism-based CYP450 inhibition
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NC3Rs Poster event 2007 - Computer models for replacing animal kinetic studies
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9th European ISSX 2006 meeting poster - Development of high-throughput assays for the screening of reversible and mechanism - based cytocrome P450 inhibition by test compounds
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9th European ISSX 2006 Meeting poster - Development of high-throughput PAMPA as an in vitro model of passive transcellular permeation
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