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Product Sheets

ADME PK

In Vitro Metabolism

Reaction Phenotyping
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Cytochrome P450 Induction
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Cytochrome P450 (CYP) Inhibition (IC50)
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Cytochrome P450 Inhibition (Ki)
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Hepatocyte Stability
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Low Clearance HµREL Co-culture
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Low Clearance Hepatocyte Stability
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Hepatic Uptake Assay
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Metabolite Profiling and Identification
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Plasma Stability
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Microsomal Stability
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Microsomal Binding
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S9 Stability
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Time Dependent CYP Inhibition (single point)
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Time Dependent CYP Inhibition (IC50 shift)
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Time Dependent CYP Inhibition (kinact/KI )
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PXR and AhR Nuclear Receptor Activation
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UGT Inhibition
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In Vitro Permeability and Transporters

PAMPA
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Caco-2 Permeability
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MDCK-MDR1 Permeability
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P-gp Substrate Identification
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BCRP Substrate Identification
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Human SLC Transporter Substrate Identification
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Human MRP Transporter Substrate Identification
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Preclinical Hepatic Oatp Substrate Identification
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P-glycoprotein Inhibition
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BCRP Inhibition
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Human SLC Transporter Inhibition
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BSEP, MRP2, MRP3 and MRP4 Inhibition
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Preclinical Hepatic Oatp Transporter Inhibition
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Bioanalysis

Advanced Bioanalytical Method Development, Method Transfer and Method Qualification
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Polymorphic and Non-CYP Mediated Metabolism

Monoamine Oxidase Inhibition
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Monoamine Oxidase Reaction Phenotyping
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Carboxylesterase Inhibition
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Carboxylesterase Reaction Phenotyping
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Aldehyde Oxidase Reaction Phenotyping
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Protein Binding

Blood to Plasma Ratio
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Brain Tissue Binding
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Plasma Protein Binding
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Whole Blood Binding
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toxicology

3D Microtissue Models

High Content Imaging of 3D Microtissues
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ATP Content in 3D Microtissues
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3D Hepatotoxicity Assay using HepaRG Spheroids
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3D Hypertrophy Assay
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Cardiotoxicity

hERG Safety
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eCiphr®Cardio
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3D Structural Cardiotoxicity Assay
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Genotoxicity

pH3 and pH2AX Genotoxicity
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GreenScreen HC™
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γH2AX Double Strand DNA Damage Response Assay
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Ames Test - Screening
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In Vitro Micronucleus Test - (MNT; HCS CHO-K1)
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In Vitro Micronucleus Test - (MNT; Flow cytometry TK6)
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In Vitro Comet
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Mechanistic Toxicity

Apoptosis and Necrosis Assay (Flow Cytometry)
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Phospholipidosis and Steatosis
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Lysosomal Trapping
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Hemolysis
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Reactive Metabolite
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KeratinoSens™ Skin Sensitization
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Androgen Receptor Modulation
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Phototoxicity
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Mitochondrial Toxicity

Functional Mitochondrial Toxicity Assay (Seahorse XFe96)
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Mitochondrial Respiratory Complex Assay
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Mitochondrial Biogenesis Assay
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Mitochondrial Toxicity (Glu/Gal Assay)
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Multiparametric Toxicity

Cytotoxicity Screening Panel
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CellCiphr® Premier
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Nephrotoxicity

Chronic Exposure Nephrotoxicity AssayA combined high content screening (HCS) approach using renal proximal tubule endothelial cells (RPTEC) for nephrotoxicity assessment
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Neurotoxicity

eCiphr®Neuro
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eCiphr®Neuro-Human
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Neurite Outgrowth Assay
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in silico

Physiological Modeling

chemPK
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chemTarget™
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chemTox
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DDI-Fusion Predictor
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Cloe PK
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Cloe HIA
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Software and Workflow

Discovery Bus
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physicochemical profiling

Physicochemical Properties

Chemical Stability
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log D
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pKa and log P Determination
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Thermodynamic Solubility
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Turbidimetric Solubility
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