Drug toxicity, often manifested as liver toxicity and cardiotoxicity, is a key reason for drug attrition. Identifying potential toxicity at an early stage in drug discovery can save both time and developmental costs, and most importantly reduce the likelihood of late stage failure.
Cyprotex is the ideal partner to assist you in understanding the toxic liability of your compounds using a panel of different techniques. We can help identify which compounds have the optimal ADME and safety profile to advance into the clinic. Our focus on state of the art technology and automation allow for high quality data to be generated rapidly and cost-effectively.
To that end, Cyprotex have invested in several high content screening (HCS) platforms that use automated fluorescence imaging to simultaneously analyze multi-parametric indicators of cytotoxicity. This improves the prediction of toxicological events and allows for a better understanding of the mechanisms of drug toxicity.
Our CellCiphr® technology was acquired from Cellumen in 2010. The technology provides a thorough assessment of potential mechanisms of toxicity using a HCS platform and links to exposure (Cmax) levels to understand the clinical relevance of the data. In 2013, we launched a new assay (eCiphr®Cardio) to evaluate cardiotoxicity in human iPS cell-derived cells using microelectrode array. This service has the advantage that it determines whole cell electrophysiology for all major ion channels in synchronously beating cardiomyocytes. Using the same microelectrode assay platform, we have also developed in vitro CNS cell-based assays (eCiphr®Neuro and eCiphr®Neuro-Human) to evaluate neuronal activity using rat primary cortical neurons or human iPSC-derived co-cultures of neurons and astrocytes.