Cyprotex is a specialist provider of ADME and PK services and provide a range of in vitro drug-drug interaction assays.
The most common types of metabolic drug-drug interactions are the inhibition and induction of the drug metabolising enzymes. These interactions can cause increased or decreased drug exposures when two or more drugs are co-administered. For example, cytochrome P450 inhibition (CYP450) may increase the plasma levels of co-administered drugs leading to toxicity. Conversely, if a CYP450 enzyme is induced it may increase the metabolism of the co-administered compound; this can reduce plasma levels resulting in decreased efficacy or an increased formation of a toxic metabolite.